A NEW STRAIGHTFORWARD FORMATION OF AMINOISOXAZOLES FROM ISOCYANIDES

The reaction of alpha-bromoketone oximes with isocyanides and sodium c arbonate leads to a new formation of 5-aminoisoxazole derivatives. The reaction probably involves the intermediacy of a nitrosoalkene genera ted in situ. Good yields are obtained for electron deficient ketone ox imes such as ethyl bromopyruvate oxime; the use of a trifluoromethyl s ubstituted oxime gives a high efficient formation of trifluoromethyl i soxazoles. (C) 1997 Published by Elsevier Science Ltd.