AN IMPROVED SYNTHESIS AND SELECTIVE COUPLING OF A HYDROXY BASED PHOTOLABILE LINKER FOR SOLID-PHASE ORGANIC-SYNTHESIS

Authors
WHITEHOUSE DL SAVINOV SN AUSTIN DJ
Citation
Dl. Whitehouse et al., AN IMPROVED SYNTHESIS AND SELECTIVE COUPLING OF A HYDROXY BASED PHOTOLABILE LINKER FOR SOLID-PHASE ORGANIC-SYNTHESIS, Tetrahedron letters, 38(45), 1997, pp. 7851-7852
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
45
Year of publication
1997
Pages
7851 - 7852
Database
ISI
SICI code
0040-4039(1997)38:45<7851:AISASC>2.0.ZU;2-0
Abstract
Photolabile linkers have become an important orthogonal technique for substrate cleavage off the resin in solid-phase organic synthesis. Her ein, we report an improved synthesis and selective coupling of a hydro xy based photolinker to a hydroxy based solid-phase resin, thereby rem oving the necessity for protection or on-resin manipulation. (C) 1997 Elsevier Science Ltd.