HYDROXYMETHYLATION OF ORGANIC HALIDES - EVALUATION OF A CATALYTIC-SYSTEM INVOLVING A FLUOROUS TIN HYDRIDE REAGENT FOR RADICAL CARBONYLATION

Authors
RYU I NIGUMA T MINAKATA S KOMATSU M HADIDA S CURRAN DP
Citation
I. Ryu et al., HYDROXYMETHYLATION OF ORGANIC HALIDES - EVALUATION OF A CATALYTIC-SYSTEM INVOLVING A FLUOROUS TIN HYDRIDE REAGENT FOR RADICAL CARBONYLATION, Tetrahedron letters, 38(45), 1997, pp. 7883-7886
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
45
Year of publication
1997
Pages
7883 - 7886
Database
ISI
SICI code
0040-4039(1997)38:45<7883:HOOH-E>2.0.ZU;2-7
Abstract
Hydroxymethylation of organic halides 2 using a catalytic amount of fl uorous tin hydride 1, CO, and NaBH3CN as a reducing agent, proceeded s moothly to give one-carbon homologated alcohols 5 in good yields. Thre e phase workup (water-dichloromethane-perfluorohexane) was convenientl y performed for the separation of 1 and 5. (C) 1997 Elsevier Science L td.