Objectives: To describe the role and current status of vaccine researc
h against sexually transmitted diseases (STDs). Methods: The available
literature was reviewed with particular emphasis on bacterial STDs. R
esults: Strategic approaches to possible implementation of STD vaccine
programmes were analysed. The status of vaccines against bacterial ST
Ds (syphilis, chancroid, gonorrhoea, and chlamydia) is described in de
tail. Conclusions: The development of safe and effective STD vaccines
offers a potent tool for the control of STDs, including direct and ind
irect prevention of HIV infection. Future priorities should be in the
development of vaccines against gonorrhoea, chlamydia, and syphilis. W
hen such vaccines become available, caution should be exercised to ens
ure that they do not interfere with the effectiveness of other prevent
ion programmes.