ORIAMIDE, A NEW CYTOTOXIC CYCLIC PEPTIDE-CONTAINING A NOVEL AMINO-ACID FROM THE MARINE SPONGE THEONELLA SP

Authors
CHILL L KASHMAN Y SCHLEYER M
Citation
L. Chill et al., ORIAMIDE, A NEW CYTOTOXIC CYCLIC PEPTIDE-CONTAINING A NOVEL AMINO-ACID FROM THE MARINE SPONGE THEONELLA SP, Tetrahedron, 53(47), 1997, pp. 16147-16152
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
53
Issue
47
Year of publication
1997
Pages
16147 - 16152
Database
ISI
SICI code
0040-4020(1997)53:47<16147:OANCCP>2.0.ZU;2-P
Abstract
A novel cyclic peptide, oriamide (1) containing the new 4-propenoyl-2- tyrosylthiazole amino acid (PTT), was isolated from the marine sponge Theonella sp. collected in Sodwana Bay. The structure of oriamide, inc luding the absolute configuration of all amino acids, was elucidated b y spectroscopic analysis and degradation experiments. (C) 1997 Elsevie r Science Ltd.