NOVEL BIOACTIVE PHENANTHRENE DERIVATIVES FROM DOMOHINEA-PERRIERI

Four novel phenanthrene derivatives were isolated from Domohinea perri eri Leandri (Euphorbiaceae) collected in Madagascar, and have been str ucturally assigned as 3,6-dihydroxy-1,7-dimethyl-9-methoxyphenanthrene (1), oxy-1-hydroxymethyl-9-methoxy-7-methylphenanthrene (2), oxy-7-hy droxymethyl-9-methoxy-1-methylphenanthrene (3), and ihydroxy-1,7-dihyd roxymethyl-9-methoxyphenanthrene (4), respectively. A further constitu ent was the navel hexahydrophenanthrene derivative, domohinone (5), wh ose structure was confirmed by single-crystal X-ray crystallography. C ompounds 1-5 were evaluated for cytotoxic and bleomycin-mediated DNA s trand-scission activities. (C) 1997 Elsevier Science Ltd.