NEUROLEPTIC INTOLERANCE

This article reviews antipsychotic medication side effects, especially those that require the physician to discontinue or the patient to be noncompliant with otherwise useful medication. They include such commo n problems as extrapyramidal syndromes (dystonia, akathisia, drug-indu ced Parkinsonism, tardive dyskinesia), sedation, weight gain, and sexu al dysfunction, as well as less frequent concerns, such as seizures, n euroleptic malignant syndrome, agranulocytosis, torsade de pointes, he patitis, and dermatological and ophthalmological syndromes. The advers e events associated with some of the new antipsychotic drugs are inclu ded. Available information about individual susceptibility to side eff ects is addressed by syndrome.