SYNTHESIS AND EVALUATION OF THE HYBRID MOLECULES POSSESSING DNA-CLEAVING ACTIVITY

Authors
SHISHIDO K HARUNA S YAMAMURA C IITSUKA H NEMOTO H SHINOHARA Y SHIBUYA M
Citation
K. Shishido et al., SYNTHESIS AND EVALUATION OF THE HYBRID MOLECULES POSSESSING DNA-CLEAVING ACTIVITY, Bioorganic & medicinal chemistry letters, 7(20), 1997, pp. 2617-2622
Citations number
29
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
20
Year of publication
1997
Pages
2617 - 2622
Database
ISI
SICI code
0960-894X(1997)7:20<2617:SAEOTH>2.0.ZU;2-6
Abstract
The design and synthesis of enantiomerically enriched hybrid molecules , la-e and 2a-c, have been accomplished by employing the lipase-mediat ed asymmetric acetylation of prochiral diol 9 as the key step. Evaluat ion of their DNA-cleaving activity has revealed the unnatural type of enantiomer 2a-c to be more potent than la-e with natural configuration . (C) 1997 Elsevier Science Ltd.