SOLID-PHASE SYNTHESIS OF A N-CARBOXYALKYL TRIPEPTIDE COMBINATORIAL LIBRARY

Authors
ESSER CK KEVIN NJ YATES NA CHAPMAN KT
Citation
Ck. Esser et al., SOLID-PHASE SYNTHESIS OF A N-CARBOXYALKYL TRIPEPTIDE COMBINATORIAL LIBRARY, Bioorganic & medicinal chemistry letters, 7(20), 1997, pp. 2639-2644
Citations number
29
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
20
Year of publication
1997
Pages
2639 - 2644
Database
ISI
SICI code
0960-894X(1997)7:20<2639:SSOANT>2.0.ZU;2-K
Abstract
A combinatorial library of N-carboxyalkyl tripeptides was prepared to generate new leads against metalloproteinases. Using the base labile T entaGel S HMB resin, an Fmoc strategy was employed to yield 100 mixtur es of 200 compounds each of the general structure 5. A synthetic proto col combining both mix and split and indexed combinatorial strategies was used,and selected inhibition data against MMP-3 is reported. (C) 1 997 Elsevier Science Ltd.