DESIGN AND SYNTHESIS OF CURACIN-A ANALOGS WITH VARIED SIDE-CHAIN STRUCTURES

Authors
NISHIKAWA A SHIRAI R KOISO Y HASHIMOTO Y IWASAKI S
Citation
A. Nishikawa et al., DESIGN AND SYNTHESIS OF CURACIN-A ANALOGS WITH VARIED SIDE-CHAIN STRUCTURES, Bioorganic & medicinal chemistry letters, 7(20), 1997, pp. 2657-2660
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
20
Year of publication
1997
Pages
2657 - 2660
Database
ISI
SICI code
0960-894X(1997)7:20<2657:DASOCA>2.0.ZU;2-X
Abstract
A series of side chain-modified analogs of curacin A, a powerful antim itotic agent isolated from a Caribbean cyanobacterium was synthesized and the effect of these compounds on in vitro microtubule polymerizati on was examined. The analogs showed weak or no anti-tubulin activity, suggesting that the whole side chain structure of curacin A is require d for the interaction with tubulin. (C) 1997 Elsevier Science Ltd.