SITE-SPECIFIC INCORPORATION OF PHOTOISOMERIZABLE AZOBENZENE GROUPS INTO RIBONUCLEASE-S

Authors
LIU D KARANICOLAS J YU C ZHANG ZH WOOLLEY GA
Citation
D. Liu et al., SITE-SPECIFIC INCORPORATION OF PHOTOISOMERIZABLE AZOBENZENE GROUPS INTO RIBONUCLEASE-S, Bioorganic & medicinal chemistry letters, 7(20), 1997, pp. 2677-2680
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
20
Year of publication
1997
Pages
2677 - 2680
Database
ISI
SICI code
0960-894X(1997)7:20<2677:SIOPAG>2.0.ZU;2-A
Abstract
Syntheses of S-peptide analogues bearing phenylazophenylalanine (Pap) residues at positions 4, 8, and 11 are described. Noncovalent reassoci ation of the Pap-4 and Pap-11 peptides with S-protein reconstitutes ri bonuclease activity. Photoisomerization of the Pap-4 peptide is found to modulate the enzyme activity. (C) 1997 Elsevier Science Ltd.