SDS-SUBTILISIN COMPLEX EFFICIENTLY CATALYZES SYNTHESIS OF PEPTIDES INETHANOL AND 2-PROPANOL

Authors
GETUN IV FILIPPOVA IY LYSOGORSKAYA EN OKSENOIT ES ANISIMOVA VV KOLOBANOVA SV BACHEVA AV STEPANOV VM
Citation
Iv. Getun et al., SDS-SUBTILISIN COMPLEX EFFICIENTLY CATALYZES SYNTHESIS OF PEPTIDES INETHANOL AND 2-PROPANOL, Bioorganic & medicinal chemistry letters, 7(20), 1997, pp. 2691-2696
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
20
Year of publication
1997
Pages
2691 - 2696
Database
ISI
SICI code
0960-894X(1997)7:20<2691:SCECSO>2.0.ZU;2-Z
Abstract
An enzymatic synthesis of tripeptide Z-Ala-Ala-Leu-pNA, tetrapeptides Z-Ala-Ala-P-1-P-1'-Xaa, where P-1 = Leu, Trp, Met, Ala, Ile, Phe; P-1' = Phe, Ala, Leu; Xaa = pNA, NH2, pentapeptides Z-Ala-Ala-Leu-Ala-Ala- pNA and Z-Ala-Ala-Leu-Ala-Phe-pNA is described. The reactions were per formed in organic solvents using SDS-subtilisin complex as a catalyst of the peptide bond synthesis. (C) 1997 Elsevier Science Ltd.