A CLINICAL-EVALUATION OF PULMONARY-FUNCTION IN NORMAL AND COMPROMISEDDOGS DURING PROPOFOL ANESTHESIA ADMINISTRATION

Respiratory parameters were evaluated during propofol anesthesia (Rapi novet, Propofol:Mallinckrodt Veterinary, Inc., Mundelein, IL) to deter mine the comparative effects of propofol anesthesia on normal and card iopulmonary compromised dogs. In addition the effectiveness of noninva sive monitoring during these altered conditions was compared to arteri al blood gas analysis techniques. Eighteen adult Beagles were randomly divided into four groups in the study which was designed to provide v eterinary clinicians additional information useful in the management o f either normal or critically ill patients during propofol anesthesia administration. In Part 1, study objectives, material and methods, and study design and anesthetic protocol were reviewed. Monitoring anesth etic assessment, the sequence of events and statistical analysis were also discussed. Part 2 provides results, discussion, and the conclusio n that although it is well documented that propofol can cause respirat ory depression at anesthesia dosages, the use of respiratory monitors and supplemental oxygen administration significantly improves safety a nd function even in cardiopulmonary compromised dogs.