SYNTHESIS AND ANTIMALARIAL ACTIVITY IN-VITRO AND IN-VIVO OF A NEW FERROCENE-CHLOROQUINE ANALOG

The antimalarial activities of ferrocenic compounds mimicking chloroqu ine and active upon chloroquine-resistant strains of Plasmodium falcip arum were evaluated. Four 7-chloro-4-[[[2-[(N,N-substituted amino)meth yl]ferrocenyl]methyl]amino] quinoline derivatives have been synthesize d; one of them, la, showed high potent antimalarial activity in vivo o n mice infected with Plasmodium berghei N. and Plasmodium yoelii NS. a nd was 22 times more potent against schizontocides than chloroquine in vitro against a drug-resistant strain of P. falciparum.