3-(ACYLOXY)PROPANOLAMINES - AGENTS WITH BETA-ADRENERGIC BLOCKING ACTIVITY

Authors
LEUSCHNER J SCHAFER H LEUSCHNER F
Citation
J. Leuschner et al., 3-(ACYLOXY)PROPANOLAMINES - AGENTS WITH BETA-ADRENERGIC BLOCKING ACTIVITY, European journal of medicinal chemistry, 29(3), 1994, pp. 241-243
Citations number
11
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
29
Issue
3
Year of publication
1994
Pages
241 - 243
Database
ISI
SICI code
0223-5234(1994)29:3<241:3-AWBB>2.0.ZU;2-8
Abstract
A series of totally aliphatic 3-(acyloxy)propanolamine derivatives wer e prepared and their pA2-values were determined employing the guinea-p ig atrium. Compounds with an acetyl or methyl succinoyl half ester moi ety showed a pronounced beta1-adrenergic blocking activity.