PRODUCTION OF INTERLEUKIN-6 AND TUMOR-NECROSIS-FACTOR-ALPHA IN-VITRO IS REDUCED IN WHOLE-BLOOD OF SEVERELY MALNOURISHED CHILDREN

Authors
DOHERTY JF GOLDEN MHN REMICK DG GRIFFIN GE
Citation
Jf. Doherty et al., PRODUCTION OF INTERLEUKIN-6 AND TUMOR-NECROSIS-FACTOR-ALPHA IN-VITRO IS REDUCED IN WHOLE-BLOOD OF SEVERELY MALNOURISHED CHILDREN, Clinical science, 86(3), 1994, pp. 347-351
Citations number
29
Categorie Soggetti
Medicine, Research & Experimental
Journal title
Clinical science → ACNP
ISSN journal
01435221
Volume
86
Issue
3
Year of publication
1994
Pages
347 - 351
Database
ISI
SICI code
0143-5221(1994)86:3<347:POIATI>2.0.ZU;2-Q
Abstract
1. Cytokine production in vitro was assessed in 16 malnourished childr en, before and after nutritional recovery. 2. Tumour necrosis factor-a lpha and interleukin-6 were measured in whole blood after lipopolysacc haride stimulation. 3. The total amount of both cytokines was signific antly less after 24 h incubation among malnourished children when comp ared with the same children after nutritional rehabilitation. 4. Cytok ine production in vitro is impaired in severely malnourished children.