SYNTHESIS AND CALCIUM-CHANNEL BLOCKING ACTIVITY OF 4-INDOLYL-1,4-DIHYDROPYRIDINES

Authors
LAVILLA R GOTSENS T SANTANO MC BOSCH J CAMINS A ARNAU N ESCUBEDO E CAMARASA J PALLAS M
Citation
R. Lavilla et al., SYNTHESIS AND CALCIUM-CHANNEL BLOCKING ACTIVITY OF 4-INDOLYL-1,4-DIHYDROPYRIDINES, Bioorganic chemistry, 25(3), 1997, pp. 169-178
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear",Biology
Journal title
Bioorganic chemistry → ACNP
ISSN journal
00452068
Volume
25
Issue
3
Year of publication
1997
Pages
169 - 178
Database
ISI
SICI code
0045-2068(1997)25:3<169:SACBAO>2.0.ZU;2-P
Abstract
A series of indolyldihydropyridines has been designed, synthesized, an d evaluated in order to show the effect of the indole moiety and the r ole of the methyl groups at the 2 and 6 positions of the dihydropyridi ne ring in the calcium channel blocking activity. The results seem to show that these groups constitute a critical structural requirement fo r the pharmacological action of these compounds. (C) 1997 Academic Pre ss.