CYTOCHROME-P-450 3A - INTERACTIONS WITH DERMATOLOGICAL THERAPIES

Recent case reports and studies suggest that interactions involving th e cytochrome P-450 mixed function oxidase system are important causes of medication toxicity and decreased efficacy during combination drug therapy. The cytochrome P-450 3A3/4 isoenzyme is involved in many sign ificant drug interactions. New and familiar drugs continue to be impli cated as having potentially serious interactions with this group of en zymes. An understanding of the basic principles of these interactions may have a major impact on patient outcome.