DYNAMICS OF CANDIDA ISOLATIONS FROM HUMANS FROM 1992-1995 IN GREIFSWALD, GERMANY

In the period 1992-95 there was a significant shift in the spectrum of Candida species in the University Hospital in Greifswald. During this time, the annual number of specimens taken for mycological investigat ions of adults increased threefold (total n=11 568). The isolation rat e of Candida species was 50.5%. The percentage of C. albicans isolates decreased from 76% to 54.4% with the lowest level in 1994. The opposi te trend in the occurrence of non-C. albicans species was seen, for ex ample the occurrence of C. glabrata, from 11.7% to 28.4%. We found onl y 98 strains of C. parapsilosis (1.4%) during-the 4 years. The occurre nce of Candida species in a variety of habitats was different. During the 4 years, the same annual percentages of C. albicans (mean 87.9%) w ere isolated from endoscopic oesophageal smears, whereas the distribut ion of Candida yeasts from the oral cavity, the respiratory tract, fae ces and urine had changed. Over the years, at these locations, C. albi cans was less frequently isolated and non-C. albicans species clearly increased. The highest occurrence of C. glabrata was found in urine, i n which the isolation percentage almost doubled from 23.1% to 40.9% in 1994. In contrast to adults, in all specimens originating from a paed iatric clinic that included neonatology the occurrence of C. albicans was high (83.5% in 1995), but the isolation rate of Candida species wa s low (12.3%). These results are important because of the differences in yeast susceptibility, of non-C. albicans species in particular, aga inst antifungal drugs.