Background. Prescribed medication is a mainstay of primary care but it
is clear that a large proportion of treatment is not taken correctly.
Such 'non-compliance' is considered to be a major problem, but resear
ch to date has provided few solutions. There have been increasing call
s for a change in approach in order to gain a deeper understanding of
why the problem remains and new ways of addressing it. Objectives. We
aimed to investigate how adult primary care patients perceived medicat
ion-taking using a Grounded Theory methodology. Method. Fifty general
practice patients without major current mental health or recreational
drug abuse problems were interviewed at home using a flexible intervie
w schedule. Subjects' accounts of taking prescribed treatments were ve
rified where possible by tablet counts or case-record review, six inte
rviews being excluded as unreliable. Medication use was discussed for
159 prescribed treatments of which 34 were reportedly not taken as dir
ected. Results. The analysis is presented as a model of decision makin
g which suggests that: (i) knowledge (about disease and treatment) com
bined with faith in the doctor produces the motivation to start using
medicines; (ii) most patients test a medicine before accepting it full
y; (iii) three types of medicine user exist: those who (a) passively a
ccept treatment advice, i.e. try to take the medicine as they perceive
the doctor wants them to, (b) actively use medicines, i.e. take it as
they decide they want to, and (c) reject medication altogether; (iv)
the process of accepting a treatment is closely linked to accepting th
e illness; and (v) practical problems are a late obstacle which only p
lay a small part in the process. Conclusions. These concepts have been
organized within a comprehensive model of the decision-making process
, which is discussed with reference to other current theories of medic
ation use. Researchers and clinicians must move beyond compliance when
assessing or trying to improve medication use. Making the medication-
testing process explicit is proposed as one way of assisting patients
to use treatments better.