DETECTION OF EBV RNA (EBER-1 AND EBER-2) IN MALARIA LYMPH-NODES BY IN-SITU HYBRIDIZATION

Authors
FACER C KHAN G
Citation
C. Facer et G. Khan, DETECTION OF EBV RNA (EBER-1 AND EBER-2) IN MALARIA LYMPH-NODES BY IN-SITU HYBRIDIZATION, Microbiology and immunology, 41(11), 1997, pp. 891-894
Citations number
17
Categorie Soggetti
Microbiology,Immunology
Journal title
Microbiology and immunology → ACNP
ISSN journal
03855600
Volume
41
Issue
11
Year of publication
1997
Pages
891 - 894
Database
ISI
SICI code
0385-5600(1997)41:11<891:DOER(A>2.0.ZU;2-4
Abstract
Acute Plasmodium falciparum malaria in African children allows expansi on of latent Epstein-Barr virus infection, leading to colonization of lymph nodes by virus-infected lymphoblasts in 60% of cases as demonstr ated by in situ hybridization for the detection of EBER-1 and EBER-2 R NA, This probably arises against a background of malaria-induced immun osuppression to EBV and concurrent lymphoid activation, The relevance of the results to the pathogenesis of African endemic Burkitt's lympho ma is discussed.