PROTECTIVE IMMUNITY INDUCED BY VACCINATION WITH 2 HAEMONCHUS-CONTORTUS EXCRETORY-SECRETORY PROTEINS IN SHEEP

Authors
SCHALLIG HDFH VANLEEUWEN MAW CORNELISSEN AWCA
Citation
Hdfh. Schallig et al., PROTECTIVE IMMUNITY INDUCED BY VACCINATION WITH 2 HAEMONCHUS-CONTORTUS EXCRETORY-SECRETORY PROTEINS IN SHEEP, Parasite immunology, 19(10), 1997, pp. 447-453
Citations number
34
Categorie Soggetti
Immunology,Parasitiology
Journal title
Parasite immunology → ACNP
ISSN journal
01419838
Volume
19
Issue
10
Year of publication
1997
Pages
447 - 453
Database
ISI
SICI code
0141-9838(1997)19:10<447:PIIBVW>2.0.ZU;2-4
Abstract
Two excretory secretory, (ES) antigens of adult Haemonchus contortus w ith molecular weights of 15 and 24 kDa, respectively, were evaluated a s protective immunogen against haemonchosis. Sheep were vaccinated thr ee times and subsequently challenged with 20000 infective larvae. Vacc ination induced significant reduction (>70%) in mean faecal egg counts and abomasal worm burden compared to the non-vaccinated control group or adjuvant control group. Vaccination induced ES-specific antibodies and stimulated infiltration of mast cells in the abomasal tissue.