A NEW SCALARANE SESTERTERPENOID FROM THE MARINE SPONGE CACOSPONGIA MOLLIOR

Authors
DEROSA S PULITI R CRISPINO A DEGIULIO A MATTIA CA MAZZARELLA L
Citation
S. Derosa et al., A NEW SCALARANE SESTERTERPENOID FROM THE MARINE SPONGE CACOSPONGIA MOLLIOR, Journal of natural products, 57(2), 1994, pp. 256-262
Citations number
17
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
57
Issue
2
Year of publication
1994
Pages
256 - 262
Database
ISI
SICI code
0163-3864(1994)57:2<256:ANSSFT>2.0.ZU;2-Q
Abstract
A new sesterterpene, 12-deacetoxyscalaradial [2a] has been isolated fr om the sponge Cacospongia mollior, together with the previously descri bed scalaradial [2b] and furoscalarol [3]. The structure of the new co mpound, proposed by spectral data, was confirmed by X-ray diffraction analysis. Compound 2a is the first scalarane sesterterpenoid, without a substituent at C-12, to have been identified in nature. It shows hig h antifeedant activity and is hot to taste for the human tongue. Both 2a and 2b display cytotoxic activity.