2 NEW MACROLIDE SESQUITERPENE PYRIDINE ALKALOIDS FROM MAYTENUS EMARGINATA - EMARGINATINE-G AND THE CYTOTOXIC EMARGINATINE-F

Authors
KUO YH KING ML CHEN CF CHEN HY CHEN CH CHEN K LEE KH
Citation
Yh. Kuo et al., 2 NEW MACROLIDE SESQUITERPENE PYRIDINE ALKALOIDS FROM MAYTENUS EMARGINATA - EMARGINATINE-G AND THE CYTOTOXIC EMARGINATINE-F, Journal of natural products, 57(2), 1994, pp. 263-269
Citations number
11
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
57
Issue
2
Year of publication
1994
Pages
263 - 269
Database
ISI
SICI code
0163-3864(1994)57:2<263:2NMSPA>2.0.ZU;2-D
Abstract
Two new macrolide sesquiterpene pyridine alkaloids, emarginatine F [1] and emarginatine G [2], were isolated from Maytenus emarginata. The s tructural determinations of 1 and 2 by 2D nmr techniques and spectral comparison with a related compound, emarginatine A [3], are discussed. Biological evaluation showed that emarginatine F [1] demonstrated str ong cytotoxicity against human epidermoid carcinoma of the nasopharynx (KB), ileocecal adenocarcinoma (HCT-8), melanoma (RPMI-7951) and medu lloblastoma (TE-671) tumor cells, and against murine leukemia (P-388).