THE MACROPHAGE-MIGRATION INHIBITORY FACTOR MIF IS A PHENYLPYRUVATE TAUTOMERASE

Authors
ROSENGREN E AMAN P THELIN S HANSSON C AHLFORS S BJORK P JACOBSSON L RORSMAN H
Citation
E. Rosengren et al., THE MACROPHAGE-MIGRATION INHIBITORY FACTOR MIF IS A PHENYLPYRUVATE TAUTOMERASE, FEBS letters, 417(1), 1997, pp. 85-88
Citations number
37
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
417
Issue
1
Year of publication
1997
Pages
85 - 88
Database
ISI
SICI code
0014-5793(1997)417:1<85:TMIFMI>2.0.ZU;2-8
Abstract
A macrophage migration inhibitory factor (MIF), originally described a s a product of activated lymphocytes, has been defined as a 12 kDa pro tein, expressed in a wide variety of tissues. Here MIP is identified a s a phenylpyruvate tautomerase (EC 5.3.2.1) having p-hydroxyphenylpyru vate and phenylpyruvate as its natural substrates. The definition of M IF as an enzyme may yield insight into the mechanism of action of this proinflammatory and immunomodulating cytokine. (C) 1997 Federation of European Biochemical Societies.