ANTIOXIDANT PROBUCOL REGULATES INTENSITY OF FREE-RADICAL LIPID-PEROXIDATION IN THE BLOOD OF PATIENTS WITH CORONARY ATHEROSCLEROSIS

Two series of studies were made to assess probucol medicines (lipomal, ''Alkaloid''; fenbutol ''Akrikhin'') effect on clinical symptoms, lip id metabolism, primary and secondary products of lipid peroxidation, a ctivity of antioxidant enzymes (superoxide dismutase, glutathione pero xidase) in atherosclerotic patients with hyperlipidemia type IIA and I IB. In both series probucol reduced frequency of anginal attacks, cont ent of total cholesterol and LDL cholesterol. HDL cholesterol remained unchanged or reduced insignificantly. Lipoperoxides and malonic diald ehyde levels in plasma progressively lowered against activation of ant ioxidant enzymes. These biochemical parameters returned to initial val ues within 3 months since the drug discontinuation. It is evident that antiatherogenic effect of probucol is due to indirect activation of n atural defense systems responsible for enzymic detoxication of active oxygen forms and lipoperoxides rather than to direct interaction of th is synthetic antioxidant with lipid radicals.