COMBINATION OF TALINOLOL (CORDANUM) WITH NIFEDIPINE (CORINFAR-RETARD)IN THE TREATMENT OF ECTOPIC ARRHYTHMIAS IN SICK SINUS SYNDROME IN PATIENTS WITH ISCHEMIC-HEART-DISEASE

38 patients with ischemic heart disease (IHD) and sick sinus syndrome (SSS) received combined therapy with nifedipine (corinfar-retard) and talinolol (cordanum). The former drug had a positive chronotropic effe ct on the heart, the latter's chronotropic effect was slightly negativ e. All the patients had sinus bradycardia and ectopic arrhythmia which needed therapeutic correction: supraventricular and ventricular extra systoles, fibrillation paroxysms or/and atrial flutter, paroxysmal sup raventricular tachycardia, ventricular tachycardia. Cordanum was given in a dose 50 mg twice a day, corinfar-retard 20 mg twice a day for 16 days. 30 patients responded to the treatment. In addition to good sub jective response, episodes of extrasystoles, paroxysms, flutter and fi brillation occurred much less frequently. Side effects resulted in the treatment discontinuation in 3 patients.