HUMAN ENDOMETRIAL CANCERS CONTAIN FOLLICLE-STIMULATING-HORMONE RECEPTORS - A PRELIMINARY-STUDY

In order to investigate whether human endometrial cancers contain foll icle-stimulating hormone (FSH) receptors, cancer fragments were collec ted at hysterectomy in six post-menopausal women affected by histologi cally confirmed endometrial malignancy. Cryostat sections were prepare d for in situ binding investigation. Positive endometrial glandular ce lls were registered in all cancers; I-125-FSH binding sites seemed to increase with the increasing tumor grade. Our data demonstrated for th e first time that human endometrial cancers contain specific FSH recep tors.