EFFECT OF 1-YEAR TREATMENT WITH NITRENDIPINE VERSUS ENALAPRIL ON URINARY ALBUMIN AND ALPHA-1-MICROGLOBULIN EXCRETION IN MICROALBUMINURIC PATIENTS WITH TYPE-1 DIABETES-MELLITUS - A RANDOMIZED, SINGLE-BLIND COMPARATIVE-STUDY
E. Jungmann et al., EFFECT OF 1-YEAR TREATMENT WITH NITRENDIPINE VERSUS ENALAPRIL ON URINARY ALBUMIN AND ALPHA-1-MICROGLOBULIN EXCRETION IN MICROALBUMINURIC PATIENTS WITH TYPE-1 DIABETES-MELLITUS - A RANDOMIZED, SINGLE-BLIND COMPARATIVE-STUDY, Arzneimittel-Forschung, 44-1(3), 1994, pp. 313-317
In order to compare the long-term effects of nitrendipine (CAS39562-70
-4) and enalapril (CAS 75847-73-3) on variables of glomerular and tubu
lar function in type 1 diabetes mellitus, a single-blind, randomised c
omparative 1-year study was carried out in microalbuminuric patients (
6 women, 14 men, age, 30-58 years, duration of diabetes, 3-41 years, H
b(A1c), 5.5-10 %). 10 patients were treated with 20 mg/d nitrendipine,
10 patients were treated with 10 mg/d enalapril. On the average, urin
ary albumin excretion was decreased by 38 +/- 4 % by nitrendipine (p <
0.01 vs. before treatment) and by 21 +/- 8 % by enalapril (p < 0.05 v
s. before treatment). The excretion of alpha1-microglobulin decreased
by 35 +/- 10 % and by 39 +/- 9 %, respectively (p < 0.05 vs. before tr
eatment). C reatinine clearance rose by 20 +/- 30 % during nitrendipin
e treatment (p < 0.05 vs. before treatment) but was unchanged during e
nalapril treatment. Total kidney volume decreased by 23 +/- 4 % (p < 0
.01) and by 14 +/- 6 % (p < 0.05), respectively. Blood pressure fell b
y 8 +/- 1 % (systolic) and by 13 +/- 1 % (diastolic) in nitrendipine-t
reated patients (both p < 0.01) and by 10 +/- 1 % and 13 +/- 1 % in en
alapril-treated patients (both p < 0.01). Thus, nitrendipine long-term
treatment of microalbuminuric type 1 diabetic appeared to be as effec
tive as the treatment with enalapril in preventing or postponing the p
rogression of diabetic nephropathy.