ACUTE TOXICITY AND EFFECTS ON HEPATIC OXIDATIVE DRUG-METABOLISM OF MOPYRIDONE

Mopyridone (CAS 82822-14-8) is a new chemotherapeutic with a strong an tiviral effect (vs. influenza- and toga viruses) and certain advantage s over the chemotherapeutics known so far Toxicological studies reveal its low oral and intraperitoneal toxicity in mice and rats. The 5- an d 14-day administration of mopyridone (37.5 mg/kg b.w., orally) to mal e rats established a growing tendency to the shortening of hexobarbita l sleeping time, associated with moderate changes in the hepatic oxida se activity on the 15th day, most pronounced for amidopyrine N-demethy lase (by 37%) and less for benzphetamine N-demethylase (by 17%). Anili ne hydroxylase activity was slightly diminished (by 18% and 16%, resp. ). No significant changes in the components of the electron-transport chain of cytochrome P-450 were established - the content of cytochrom e P-450, cytochrome b-5 and cytochrome C reductase, both after and 14- day mopyridone administration.