Hp. Guan et al., STUDY OF THE NUCLEOPHILIC REACTION OF 2-MERCAPTOETHANOL WITH 1-FLUOROALKYL-2-IODO-ALKENES, Journal of fluorine chemistry, 85(2), 1997, pp. 141-145
The stepwise nucleophilic addition of 2-mercaptoethanol (2) to 1-fluor
oalkyl-2-iodo-alkenes (1) was studied. Fluorine-containing building bl
ocks of a new type (4) containing a fluorine atom, a fluoroalkyl-subst
ituted double bond and a latent carbonyl group were synthesized in goo
d yield via the intermediate thioethers 3. A reasonable pathway is sug
gested. (C) 1997 Elsevier Science S.A.