NEUROLOGICAL MANIFESTATIONS OF PRIMARY SJOGRENS-SYNDROME IN JAPANESE PATIENTS

The neurological manifestations of twenty-one Japanese patients with S jogren's syndrome (SjS) were evaluated, All patients were women, and s ixteen of the twenty-one cases (76%) demonstrated objective abnormal n eurological symptoms, the most frequently observed of which was trigem inal neuropathy (50%), Multiple mononeuropathy was seen in almost one- third of the examined cases (31%), Central nervous system (CNS) involv ement was observed in three cases (14%), All of these values differed greatly from those previously reported. Therefore, this study revealed characteristic features of Japanese SjS and also implied the existenc e of different immunopathological mechanisms associated with SjS in Ja panese patients.