The aim of the present study was to determine, histochemically, the on
set and location of production of preduodenal lipase in fetal, sucklin
g, weaned and adult cats. Strong enzymatic activity was localized in t
he surface mucous cells of the gastric mucosa in animals at postpartal
day 1 after ingestion of milk. Activity of gastric lipase persisted a
s long as animals were nursed. No gastric lipase could be demonstrated
in weaned and adult cats. Lingual lipase was not found at any develop
mental stage examined. Thus, in the newborn cat, lipase of the gastric
mucosa is responsible for milk fat lipolysis.