Purpose: The presence and degree of regression were assessed from 18 t
o 30 months after photorefractive keratectomy (PRK). Methods: A total
of 449 eyes (449 patients) were treated with an Aesculap Meditec 193-n
m Arf Excimer laser. These 449 eyes were followed during the first 24
months after PRK, and 252 of these eyes were followed for 24 to 30 mon
ths, Results: Thirty (6.7%) of the 449 eyes followed for up to 24 mont
hs showed good refractive results during the first year and a half but
regressed thereafter and required retreatment. Late regression was co
nfined to subjects with pretreatment myopia above -4.0 diopters (D) an
d was the same in low-and high-myopic eyes between 18 and 24 months po
st-PRK. However, between 24 and 30 months, regression was higher in lo
w-myopic eyes, where it reached -0.55 D, than in high-myopic eyes, whe
re it was -0.21 D. This lower-frequency of regression in high-myopic e
yes is attributed to the relatively high rate of retreatment in this g
roup during the first 18 months after PRK. Conclusions: Although the f
indings indicate a fairly low rate of regression after 24 months, ther
e still are insufficient data on which to predict when regression post
-PRK stabilizes.