J. Graff et S. Fugleberg, A PROSPECTIVE-STUDY OF TRANSPERITONEAL TRANSPORT IN PATIENTS UNDERGOING PERITONEAL-DIALYSIS, Scandinavian journal of urology and nephrology, 31(5), 1997, pp. 469-475
A prospective one-year follow-up study of the functional characteristi
cs of the peritoneal membrane was conducted in 20 peritoneal dialysis
patients. Ten patients had at least one episode of peritonitis during
the follow-up period. Changes in the transperitoneal transport of smal
l solutes were evaluated by the mass transfer area coefficients (urea,
creatinine, and glucose), ultrafiltration sieving coefficients (urea
and creatinine:), and peritoneal equilibration test results. Changes i
n the capacity of the peritoneal membrane to transport macromolecules
were evaluated by means of albumin mass transfer rates. Finally, chang
es in transperitoneal water transport were evaluated by means of the u
ltrafiltration properties and the lymphatic flow rates. After one year
of follow-up, transport of water and the investigated solutes had not
changed significantly. Even episodes of peritonitis had no permanent
influence on the transport function of the peritoneal membrane. The in
traperitoneal residual volumes before instillation were significantly
larger in patients who developed peritonitis during the follow up peri
od compared to patients who did not. Over a one-year period, no change
s in peritoneal membrane characteristics could be demonstrated. A larg
e residual volume of dialysate may be a marker of increased risk of ge
tting peritonitis.