CARDIORENAL EPINEPHRINE KINETICS - EVIDENCE FOR NEURONAL RELEASE IN THE HUMAN HEART

Citation
M. Johansson et al., CARDIORENAL EPINEPHRINE KINETICS - EVIDENCE FOR NEURONAL RELEASE IN THE HUMAN HEART, American journal of physiology. Heart and circulatory physiology, 42(5), 1997, pp. 2178-2185
Citations number
26
Categorie Soggetti
Physiology
ISSN journal
03636135
Volume
42
Issue
5
Year of publication
1997
Pages
2178 - 2185
Database
ISI
SICI code
0363-6135(1997)42:5<2178:CEK-EF>2.0.ZU;2-Y
Abstract
There are experimental data suggesting that epinephrine (Epi) may act as a cotransmitter in sympathetic nerves, stimulating presynaptic beta (2)-receptors and enhancing norepinephrine (NE) release. To examine ne uronal Epi release, patients with congestive heart failure and hyperte nsion and healthy subjects were examined with the isotope-dilution met hod. At baseline, small cardiac and renal Epi spillovers were found in patients. During intense supine exercise, cardiac NE and Epi spillove rs increased concomitantly with similar magnitude, whereas no renal Ep i spillover could be detected. Blockade of neuronal uptake 1 caused a consistent decrease in both cardiac and renal fractional extractions o f NE and Epi. The present study demonstrates baseline cardiorenal Epi release in patients with congestive heart failure and renal Epi releas e in hypertensive patients. Furthermore, Epi is removed by neuronal up take in both the heart and kidney, and cardiac Epi spillover increases during exercise. This study, in contrast to other results, provides e vidence for cardiac neuronal Epi release.