REGIOSELECTIVE AND CHEMOSELECTIVE SYNTHESIS OF HALOHYDRINS BY CLEAVAGE OF OXIRANES WITH METAL-HALIDES

Recent developments in the regio-, chemo- and stereoselective oxirane cleavage by new halogenating reagents allow obtention of various vicin al halohydrins. Also, epoxy alcohols and other functionalized oxiranes can be conveniently converted into the corresponding halohydrins. Som e of the new methodologies have been successfully applied to the prepa ration of optically active fragments toward the synthesis to more comp lex molecules and natural products.