SYNTHESIS AND STRUCTURE OF (CARBOXYMETHYL)-FUNCTIONALIZED CYCLOBUTA-FUSED URACIL DIMERS

Herein, we report a convenient method for the preparation of four benz yl-ester-protected, (carboxymethyl)-functionalized cyclobuta-fused ura cil dimers 1-4, including the desired cis-cisoid-cis,syn-configured is omer 1, a compound which is suitable for the preparation of catalytic antibodies, synthetic receptors, and model corn pounds, required for t he investigation of the DNA-lesion, recognition step and DNA-repair me chanisms. A comprehensive structure determination of each isomer by H- 1-NMR, and in the case of the cis-cisoid-cis,syn-and the cis-transoid- cis,syn-dimers by X-ray crystal-structure analysis, is also provided.