We developed criteria for implantation and programming of permanent en
docardial pacemakers in patients with a nonthoracotomy ICD system. The
se criteria were prospectively used in 10 patients who recieved an ICD
prior to (n = 5) or following (n = 5) implantation of a dual chamber
(n = 6) or ventricular (n = 4) pacemaker with a unipolar (n = 4) or bi
polar (n = 6) lead configuration. All patients were tested for interac
tions or malfunctions. Undersensing of ventricular fibrillation by the
atrial sense amplifier and inadequate atrial pacing occurred in one p
atient with a unipolar dual chamber system programmed to AAIR but didn
't impair ICD sensing. Transient or permanent loss of capture or sensi
ng of the pacemaker wets not observed after ICD shocks with the output
programmed to double pulse width and voltage of stimulation threshold
and the sensitivity to 50% of the detected R wave. One episode of tra
nsient reprogramming occurred without clinical consequences. One unipo
lar ventricular pacemaker lead had to be exchanged against a bipolar l
ead because of oversensing of the pacing artifact by the ICD. There wa
s no failure of an ICD to detect ventricular arrhythmias due to inadeq
uate pacemaker activity. During a follow-up period of 21 +/- 11 months
, a total of 78 ventricular arrhythmias were effectively treated in si
x patients. Thus, a combined use of transvenous ICD and pacemaker is p
ossible despite the close vicinity of pacing and defibrillations leads
. Optimized programming different to the common settings is required.
As interactions occurred only in unipolar pacemaker leads bipolar syst
ems should be used in these patients.