EFFECT OF MIGLITOL ADMINISTRATION TO NON-INSULIN-DEPENDENT DIABETIC RATS

1. The effect of the acute or chronic oral administration of miglitol (Bay M 1099 alpha-glucosidase inhibitor) to non-insulin-dependent diab etic rats was studied. 2. The acute oral administration of miglitol (1 0 mg/kg b.w.) reduced significantly the increment of blood glucose aft er oral maltose (2 g/kg b.w.) overload (364+/-58 and 205+/-12 mmol/90 min, without and with miglitol respectively; P<0.05). 3. Under chronic oral administration of miglitol (10 mg/kg b.w.), two days after the s tart of treatment the blood glucose dropped from 7.53+/-9.59 to 4.40+/ -5.50 mmol/l. The plasma insulin, cholesterol, or triglycerides levels were not modified. 4. A significant reduction (P<0.01) in water and f ood intake was observed. Normal rats values were not affected by migli tol treatment. (C) 1998 Elsevier Science Inc.