H. Mineo et al., EFFECTS OF PROGLUMIDE ON CHOLECYSTOKININ-8-INDUCED EXOCRINE AND ENDOCRINE PANCREATIC RESPONSES IN CONSCIOUS SHEEP, Comparative biochemistry and physiology. Section A: Comparative physiology, 118(3), 1997, pp. 759-764
Citations number
40
Categorie Soggetti
Physiology,Biology
Journal title
Comparative biochemistry and physiology. Section A: Comparative physiology
The effects of cholecystokinin (CCK)-8, either alone or together with
the CCK antagonist, proglumide on both exocrine and endocrine pancreat
ic responses were examined in conscious sheep. Intravenous infusions o
f CCK-8 (120 pmol/kg/min for 40 min) with vehicle (0 mu mol/kg/min pro
glumide) significantly increased both amylase output in pancreatic jui
ce and plasma insulin concentrations (P < 0.05). Concomitant infusions
of proglumide (5-40 mu mol/kg/min for 50 min) inhibited both amylase
and insulin secretory responses induced by CCK-8 infusion. The antagon
istic effects of proglumide occurred in a dose-dependent manner, and p
roglumide infusion at dose of 20 mu mol/kg/min or above simultaneously
inhibited CCK-8-induced amylase and insulin responses. In conclusion,
although the type of receptor involved is not characterized at presen
t, exogenously infused CCK-8 acts on B cells via a CCK-receptor-mediat
ed mechanism and induces insulin secretion in sheep. (C) 1997 Elsevier
Science Inc.