Jwh. Leer et al., SELECTIVE AVOIDANCE OF POSTOPERATIVE LOCOREGIONAL RADIOTHERAPY IN BREAST-CANCER SEEMS TO BE JUSTIFIED, The European journal of surgery, 163(11), 1997, pp. 815-822
Objective: To try and reduce the amount of routine postoperative radio
therapy that we prescribed without causing an unacceptable rise in loc
oregional recurrences. Design: Retrospective study. Setting: Teaching
hospital, The Netherlands. Subjects: 836 women who were treated for br
east cancer between January 1980 and December 1989. Interventions: The
se 836 had been treated by modified radical mastectomy (n = 534), exci
sion of the tumour and axillary dissection (n = 279), lumpectomy (n =
15), or total mastectomy (n = 8). In December 1984 we stopped giving r
outine postoperative irradiation to women with T-1 or T-2 tumours unle
ss there was any doubt about the operative specimen. Main outcome meas
ures: The rate of locoregional recurrence 1985-9 compared with that fr
om 1980-December 1984. Results: Only 1 patient of 836 had a clinically
detectable recurrence in the internal mammary chain. There were only
2 recurrences in the 235 axillas that had not been irradiated. Conclus
ion: By a process of careful selection of patients for locoregional ir
radiation, the number of fields of irradiation given to patients with
breast cancer can be reduced by up to 80% without causing a rise in th
e rate of locoregional recurrences.