Since the late 1980s, experiments have been performed to influence phy
siologic and disturbed healing of bone. However, the mainly negative r
esults of animal studies, cannot be applied to the human nonunion situ
ation as long as there is no adequate animal pseudarthrosis model. Pro
spective clinical studies in various centres have resulted in success
rates of more than 50%, although the majority of patients had been tre
ated repeatedly and ineffectively with the gold standard of re-osteosy
nthesis and grafting. Since the mechanisms are not yet understood, onl
y such desperate conditions are an indication for the application of h
igh-energy extracorporal shock waves.