ATP-SENSITIVE POTASSIUM CHANNELS MEDIATE VASODILATATION PRODUCED BY CALCITONIN-GENE-RELATED PEPTIDE IN HUMAN INTERNAL MAMMARY BUT NOT GASTROEPIPLOIC ARTERIES
Tn. Luu et al., ATP-SENSITIVE POTASSIUM CHANNELS MEDIATE VASODILATATION PRODUCED BY CALCITONIN-GENE-RELATED PEPTIDE IN HUMAN INTERNAL MAMMARY BUT NOT GASTROEPIPLOIC ARTERIES, European journal of clinical investigation, 27(11), 1997, pp. 960-966
Citations number
31
Categorie Soggetti
Medicine, Research & Experimental","Medicine, General & Internal
The purpose of this study was to elucidate the mechanism of action of
calcitonin gene-related peptide-induced vasodilatation of human gastro
epiploic and internal mammary arteries. Calcitonin gene-related peptid
e (0.1-100 nmolL(-1)) elicited relaxations of pre constricted vessels,
with a significantly greater effect in the gastroepiploic artery (P <
0.05). This effect was independent of endothelium-derived vasodilatin
g substances. The response of the internal mammary artery but not the
gastroepiploic artery to calcitonin gene-related peptide was attenuate
d by glybenclamide (1.0 mu molL(-1)) (P < 0.05). In vitro autoradiogra
phy indicated that [I-125]-calcitonin gene-related peptide bound to th
e tunica media but not the endothelial cells in both types of artery,
with a significantly higher degree of binding in the gastroepiploic ar
tery. It is concluded that calcitonin gene-related peptide acts direct
ly on vascular smooth muscle via specific binding sites to induce vaso
dilatation. In addition, K-ATP channels are involved in the action of
calcitonin gene-related peptide in the internal mammary artery but not
in the gastroepiploic artery.