Impending or occured pathological fractures of long bones due to skele
tal metastases need interdisciplinary management. Surgical stabilizati
on is the first of further concomitant steps in treatment like radiati
on, hormonal or chemotherapy. For that purpose a respresentative sampl
e of metastatic tissue should be taken, so that histological and immun
ohistochemical determination can lead to an optimated supporting thera
py. Transluminal bone biopsy before planned intramedular stabilization
seems to be a suitable method, simply, safe and fast to handle.