Liver biopsies were analyzed in 21 patients with chronic renal failure
(CRF) who tested positive for Hepatitis C Virus (HCV), using Elisa II
and/or PCR. The study included 14 men and 7 women, the average age be
ing 41 years old (range: 20-65). The average span of time under dialys
is was 64 months (range: 12-192). Hbs ag. was positive in six patients
. Patients underwent biopsy for showing persistent rise of transaminas
e for more than 6 months. The modified Knodell Index was used to grade
hepatic lesions. All biopsies showed chronic hepatitis, of which 2 we
re associated with cirrhosis. Eight patients were infected with mild c
hronic hepatitis, ten were infected with moderate chronic hepatitis, a
nd only three patients had a severe lesion. Fibrosis was mild in 13 ca
ses, moderate in 6, and 2 had cirrhosis. Chronic Hepatitis C character
istic lesions analysis showed lymphoid nodules in 6 cases (29%), ducta
l epithelium lesions in 7 (33%), and steatosis in 7 (33%). Chronic HCV
infection in our patients seems to have histologic characteristics si
milar to those reported in HCV positive non CRF patients.