A 44-year-old woman suffered from limbic encephalitis, possibly caused
by herpes simplex virus. Neither CT-scanning nor MR-imaging showed a
persistent lesion. Positron emission tomography, however, indicated a
metabolic deficit in circumscript limbic structures, namely gyrus cing
uli and temporal cortices. This distribution supported the clinical di
agnosis. Moreover, it suggested a close relation of the gyrus cinguli
with the organization of limbic functions in the brain. It might suppo
rt suggestions made in the literature that the gyrus cinguli is more f
requently affected by HSV encephalitis. Further PET-studies in cases o
f limbic encephalitis would be of interest.