1D-MYO-INOSITOL 1,4,5-TRISPHOSPHATE AND 1D-MYO-INOSITOL 1,3,4,5-TETRAKISPHOSPHATE ANALOGS MODIFIED AT C-3 - SYNTHESIS OF 1D-3-C-(TRIFLUOROMETHYL)-MYO-INOSITOL 1,4,5-TRISPHOSPHATE AND 1L-CHIRO-INOSITOL 1,2,3,5-TETRAKISPHOSPHATE FROM L-QUEBRACHITOL

Authors
KOZIKOWSKI AP OGNYANOV VI FAUQ AH WILCOX RA NAHORSKI SR
Citation
Ap. Kozikowski et al., 1D-MYO-INOSITOL 1,4,5-TRISPHOSPHATE AND 1D-MYO-INOSITOL 1,3,4,5-TETRAKISPHOSPHATE ANALOGS MODIFIED AT C-3 - SYNTHESIS OF 1D-3-C-(TRIFLUOROMETHYL)-MYO-INOSITOL 1,4,5-TRISPHOSPHATE AND 1L-CHIRO-INOSITOL 1,2,3,5-TETRAKISPHOSPHATE FROM L-QUEBRACHITOL, Journal of the Chemical Society, Chemical Communications, (5), 1994, pp. 599-600
Citations number
23
Categorie Soggetti
Chemistry
Journal title
Journal of the Chemical Society, Chemical Communications → ACNP
ISSN journal
00224936
Issue
5
Year of publication
1994
Pages
599 - 600
Database
ISI
SICI code
0022-4936(1994):5<599:11A11>2.0.ZU;2-2
Abstract
The novel 3-modified 1D-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P- 3] analogues 1D-3-C-(trifluoromethyl)-myo-inositol 1,4,5-trosphosphate and 1L-chiro-inositol 1,2,3,5-tetrakisphosphate are synthesized from L-quebrachitol, and the preliminary results on their Ca2+ releasing ac tivity suggest that the Ins(1,4,5)P-3 receptor can accommodate some st eric bulk in the axial region of the 3-position of Ins(1,4,5)P-3 when the equatorial 3-hydroxy group is retained.