-HEXAHYDROINDOLIZINO[8,7-B]INDOLE-5(S)-CARBOXYLATE AS A NEW-TYPE OF BETA-TURN DIPEPTIDE MIMETIC

Authors
DELAFIGUERA N ROZAS I GARCIALOPEZ T GONZALEZMUNIZ R
Citation
N. Delafiguera et al., -HEXAHYDROINDOLIZINO[8,7-B]INDOLE-5(S)-CARBOXYLATE AS A NEW-TYPE OF BETA-TURN DIPEPTIDE MIMETIC, Journal of the Chemical Society, Chemical Communications, (5), 1994, pp. 613-614
Citations number
20
Categorie Soggetti
Chemistry
Journal title
Journal of the Chemical Society, Chemical Communications → ACNP
ISSN journal
00224936
Issue
5
Year of publication
1994
Pages
613 - 614
Database
ISI
SICI code
0022-4936(1994):5<613:-AANOB>2.0.ZU;2-C
Abstract
Molecular-modelling studies have shown that 2(S)-amino-3-oxo-11 hexahy droindolizino[8,7-b]indole-5(S)-carboxylate, stereoselectively prepare d by Pictet-Spengler reaction between H-Trp-OMe and Z-Asp(H)-OBz and s ubsequent gamma-lactamization, behaves as a type-ll' beta-turn inducin g mimetic.