COMPOSITIONAL CONSTRAINTS IN THE EXTREMELY GC-POOR GENOME OF PLASMODIUM-FALCIPARUM

Authors
MUSTO H CACCIO S RODRIGUEZMASEDA H BERNARDI G
Citation
H. Musto et al., COMPOSITIONAL CONSTRAINTS IN THE EXTREMELY GC-POOR GENOME OF PLASMODIUM-FALCIPARUM, Memorias do Instituto Oswaldo Cruz, 92(6), 1997, pp. 835-841
Citations number
30
Categorie Soggetti
Tropical Medicine
Journal title
Memorias do Instituto Oswaldo Cruz → ACNP
ISSN journal
00740276
Volume
92
Issue
6
Year of publication
1997
Pages
835 - 841
Database
ISI
SICI code
0074-0276(1997)92:6<835:CCITEG>2.0.ZU;2-K
Abstract
We have analyzed the compositional properties of coding (protein encod ing) and non-coding sequences of Plasmodium falciparum, a unicellular parasite characterized by an extremely AT-rich genome. GC% levels, bas e and dinucleotide frequencies were studied. We found that among the v arious factors that contribute to the properties of the sequences anal yzed, the most relevant are the compositional constraints which operat e on the whole genome.